Emergency crews were called to the home on the Oneida Nation of the Thames, southwest of London, at about 11 a.m. Wednesday.
Police, however, have not yet indicated how many people areunaccounted for, nor have they released any information on their ages of genders.
There was also no immediate information on what caused the blaze. The Ontario Fire Marshal’s Office has been called in to investigate.
This house fire follows a similar blaze in the southern Ontario community of Port Colborne early Wednesday in which four family members perished.
Friends and family have identified the victims as a 37-year-old mother and her two children, aged 15 and 2, plus the woman’s 83-year-old grandmother.